Diethylstilbestrol (DES) Compound

• D.E.S. is available by prescription only.

• Diethylstilbestrol (D.E.S.) is a synthetic estrogen.

• D.E.S. is used in dogs to treat...

• urinary incontinence in spayed females

• enlarged prostate

• estrogen responsive tumorsperianal gland adenomas

• pregnancy prevention

• D.E.S. increases the responsiveness of the smooth muscle of the bladder neck, tightening the muscle and preventing urine from leaking.

• D.E.S. is used as an extra-label medication veterinary medicine.

• D.E.S. can only be obtained by compounding pharmacies.

• D.E.S. is effective in spayed female dogs suffering from incontinence.

• D.E.S. Compound comes in...

• 0.2 mg

• 0.5 mg

• 0.6 mg

• 0.7 mg

• 1.0 mg

• Do not use in pets with known allergies to D.E.S.

• Never use this medication in pregnant or lactating animals.

• Pregnant women, or women trying to become pregnant, should avoid contact with D.E.S.

• Do not use in animals with cancers that may be worsened by estrogens, such as breast cancer.

• Prolonged use of D.E.S. may cause ovarian cancer.

• Excessive doses can cause a decrease in platelets, red blood cells, and white blood cells.

• D.E.S. can increase the chances of uterine infections (pyometra) in unspayed females.

• Animals should be monitored once a month during D.E.S. treatment.

• Use as directed by your veterinarian.

• Follow the instructions printed on the prescription label.

• Store D.E.S at room temperature.

• Be sure to complete the prescription to ensure a full recovery, even if your pet seems to be improving, unless instructed otherwise by your veterinarian.

• Duration of administration depends on the condition being treated, the response to the medication, and development of any adverse effects.

• Allow your pet access to plenty of water.

• Blood and platelet counts should be monitored on a regular basis.

• For use in dogs ONLY.

• Give 0.1 to 1 mg.

• Give by mouth once a day for 3 - 5 days

• After initial treatment, dose should be decreased to once a week treatment

• In the case of a missed dose of D.E.S., give it as soon as you remember or wait until it is time to give the next dose. DO NOT GIVE A DOUBLE DOSE OF D.E.S.

• In the case of an overdose of D.E.S., seek attention from your veterinarian.

• The following symptoms could be signs of an overdose...

• sudden diarrhea

• increased thirst

• unusual bruising or bleeding

• pale mucous membranes

• vaginal discharge

• Allergic reactions and serious side effects are rare, but in the case of an allergic reaction or a serious side effect, you should stop D.E.S. treatment and seek veterinary attention.

• Some common signs of an allergic reaction or more serious side effect are...

• facial swelling

• breathing difficulties

• pale mucous membranes

• vaginal discharge

• bleeding from the gastrointestinal or urinary tracts

• uterine infections (pyometra) in unspayed female dogs

• bone marrow depression