- Entering the cell wall of bacteria
- Binding to ribosomal subunits inside bacteria
- Gram-positive bacteria, like certain Strep and Staph strains
- Gram-negative bacteria, like certain Toxoplasma strains
- Is pregnant or nursing
- Has sensitivity to any macrolide antibiotic
- Has a hepatic disease
- Cisapride
- Oral antacids
- Severe diarrhea
- Worsening symptoms
- Severe vomiting